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Check Closely (1)pentobarbital will reduce the extent or influence of glecaprevir/pibrentasvir by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lower the level or effect of ketoconazole by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Not known.pentobarbital will lessen the extent or impact